First promising results for a potential COVID-19 vaccine to be tested on Canadians


HALIFAX – An early trial of a future COVID-19 vaccine that will soon be tested on Canadians has revealed that it is safe and effective in triggering an immune response.

A study published in The Lancet on Friday indicates that the formulation of CanSino Biologics Inc. in China needs more testing to determine if it can actually protect against SARS-CoV-2, the virus that causes COVID-19.

But he said the first trials involving 108 adults in Wuhan produced neutralizing antibodies and a response in T cells, which protect the body from pathogens, after 28 days. The most common side effects – described as “mild” and “moderate” – were pain at the injection site, fever, fatigue, and headache.

The results come just before researchers from Dalhousie University test the CanSino product in Halifax in the coming weeks.

Dalhousie says the first clinical trial in Canada for a potential vaccine will start with fewer than 100 people between the ages of 18 and 55. A follow-up step will involve nearly 500 people across Canada, including those aged 65 to 85.

The Beijing professor in charge of the Lancet study stresses that the results must be interpreted with caution, describing it as “a promising vision for the development of COVID-19 vaccines”.

“We are still far from the availability of this vaccine for all,” Wei Chen of the Beijing Biotechnology Institute said in a statement on Friday.

The creation of a COVID-19 vaccine is seen as a crucial step in controlling the pandemic and enabling businesses, classes, organized sport, the performing arts and social activity to resume safely.

There are more than 100 applicants in development worldwide.

According to Dr. Joanne Langley of the Canadian Center for Vaccinology in Halifax, CanSino’s partnership with the National Research Council of Canada highlights local scientific expertise and should secure a Canadian supply if the potential vaccine turns out to be viable.

“We will likely produce the vaccine on Canadian soil, which gives us security of supply,” says Langley.

The Lancet study authors note several limitations of the trial, including its small sample size, relatively short duration, and the absence of a randomized control group.

A phase 2 trial has already started in Wuhan which is randomized, double blind and placebo controlled.

This study will look for side effects up to six months after vaccination. It will also involve 500 adults, including participants over the age of 60.

The Lancet study was funded by the National Key R&D Program of China, the National Science and Technology Major Project and CanSino.


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