Emergency services, including the Thames Valley police, are currently on A4 Bath Road, with the road closed in both directions between Berkeley Avenue and Parkside Road.
A tweet from the Thames Valley police road unit indicates that the road is likely to remain closed for several hours and advises motorists to avoid the area.
The tweet says: We are at the scene of a collision on A4 Bath Road, Reading.
“The road is closed in both directions between Berkeley Avenue and Parkside Road.
“The closures should stay for several hours. Drivers are advised to avoid the area. We will update more when we can. “
BerkshireLive will bring you live updates on the incident in the blog below.