The actor, famous for his double act with Syd Little, presented a long-running sketch show on BBC One in the 1970s and 1980s.
He is reported to have contracted a coronavirus.
The Glasgow-born comedian, whose real name is Edward Hugh McGinnis, was known for his partnership with Syd Little which lasted five decades after his training in 1971.
Her son Ryan McGinnis wrote on Facebook today: “It is with great sadness that mom and I must announce that my father, Edward Mcginnis, died early in the morning.
“He suffered from heart failure and, unfortunately, at the hospital, he contracted the coronavirus, that his heart was unfortunately not strong enough to fight. “
“Dad has fought bravely for so long. Due to this horrible illness, we were unable to visit him at the hospital, but the whole family and close friends spoke to him every day.
“He will be sorely missed and we are so proud of all that he has accomplished in his career with Syd and we know that he was loved by the millions who watched them every week. Papa RIP. We love you and miss you from the whole family. “”
Matt Lucas of Little Britain paid tribute on Twitter, writing, “Eddie Large (with his supersonic friend Syd) was really lovely and kind and encouraging to me when I was a picnic on Shooting Stars. So sad to hear of her death. “