Ten Doctor Who actors from the past 50 years will later thank real doctors and other NHS staff at a BBC fundraising telethon.
Jodie Whittaker will be joined by a crowd of her predecessors as a doctor on BBC One’s The Big Night In.
Little Britain, Peter Kay, the Vicar of Dibley and Catherine Tate will also be back for the three-hour special.
The show begins at 7:00 p.m. BST and will see Children in Need and Comic Relief join forces for the first time.
Doctors recorded a message thanking front-line staff for their work during the coronavirus crisis. It will air just before the weekly Clap For Carers at 8:00 p.m. BST.
The actors who participate in it range from Tom Baker, who played the role between 1974 and 1981, to the current inhabitant of Tardis, Jodie Whittaker, and Jo Martin, who appeared as an alternative incarnation of the Doctor in two episodes earlier this year.
Other highlights of the evening included Matt Lucas and David Walliams making Little Britain on television for the first time in ten years.
Dawn French will revive the Vicar of Dibley, and Kay will unveil a new video for (Is This The Way To) Amarillo.
Tate will bring back schoolgirl Lauren – who is struggling to be educated remotely by her teacher, played by David Tennant.
The three-hour show will raise millions of pounds for vulnerable people in the UK who have been affected by the pandemic. The government has committed to match all public donations, with a minimum of £ 20 million.
The program also promises to “celebrate the acts of kindness, humor and the spirit of hope and resilience that move the nation forward.”
It will include the unveiling of a home video for a charitable single featuring stars like Dua Lipa, Chris Martin and Rita Ora.
They – along with Ellie Goulding, Jess Glynne, Paloma Faith and Rag ‘N’ Bone Man – recorded a cover of the 2003 song Foo Fighters, Times Like These.
Gary Barlow, Steve Coogan, Rob Brydon, Jack Whitehall, Romesh Ranganathan, Miranda Hart and the cast of People Just Do Nothing are among the others expected to appear in the series.
And the professionals at Strictly Come Dancing have come up with a new routine for people to learn at home.
The program will be hosted by Matt Baker, Zoe Ball, Sir Lenny Henry, Paddy McGuinness and Davina McCall.
“It’s so exciting to be able to do something positive … especially bringing Comic Relief and Children In Need together for one night,” McCall told BBC Radio 5 Live on Wednesday.
“We’re actually going to be in a studio, which I personally love – being in the same room as the others.
“We are going to be in the BBC One Show studio, so there will be Matt, Lenny and me for the first hour and we will all be two meters apart. “
Sir Lenny told BBC Breakfast on Saturday, “We are all going to be socially distant, then do a little bit, then get away from each other, then almost everyone does stuff at home or from a distance. This is going to be great! “
The purpose of the evening is to let “key workers and caregivers know that we really respect what they do,” he said.
Speaking of fundraising, he added, “A lot of the projects we support got to us and said they were really in trouble right now. They need our help. “
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